Avancerad sökning

Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

   Författare :Jones Ofori; Diabetes - öcellsexocytos; []
   Nyckelord :T2D; insulin secretion; exocytosis; ncRNAs; GAS5; miR-152; miR-335; miR-130a b; miR-375; STXBP1; SNAP25; SYT13; PDHA1; PDX1; glucocortiocoid; beta cell function; glucose metabolism;

   Sammanfattning : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. LÄS MER

3. 2. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

   Författare :Sofia A Andersson; Diabetes - öcellsexocytos; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

   Sammanfattning : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). LÄS MER