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1. 1. The evolution of respiratory chain complex I from smaller functional modules

   Författare :Vamsi Moparthi; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hyf; Hyc; Membrane bound hydrogenases; NADH:quinone oxidoreductase; Mrp antiporter; 16S rRNA;

   Sammanfattning : NADH:quinone oxidoreductase, or complex I, is a large membrane bound enzyme in the respiratory chain of living organisms, that has evolved from the combination of smaller functional building blocks. The enzyme has a conserved core structure, comprising 14 protein subunits: Seven subunits protrude from the membrane and contain a flavin and eight iron-sulfur clusters. LÄS MER

3. 2. Painfully Energetic : A tale of two proteins potentially connected

   Författare :Eva Sperling; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complex I; Mrp-antiporter; Membrane bound hydrogenases; TRP ion channels; TRPA1; thermosensation; chemosensation; 23Na-NMR;

   Sammanfattning : NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. LÄS MER