Sökning: "ICMT"

Hittade 2 avhandlingar innehållade ordet ICMT.

1. 1. Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer

   Författare :Annika Wahlström; Göteborgs universitet; []
   Nyckelord :RCE1; ICMT; K-RAS; CAAX proteins; MPD; lung cancer;

   Sammanfattning : CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) of the CAAX motif by farnesyltransferase (FTase) or geranylgeranyltransferase-I (GGTase-I); second, the –AAX are removed by RAS converting enzyme 1 (RCE1); and third, the cysteine is methylated by isoprenylcysteine carboxyl methyltransferase (ICMT). LÄS MER

3. 2. Defining the role of CAAX protein proteolysis and methylation in the pathogenesis and treatment of progeria

   Författare :Xue Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a rare childhood disease characterized by failure to thrive, bone abnormalities, hair loss, and a shortened life span due to cardiovascular disease, and nuclear shape abnormalities in cultured cells. HGPS is caused by de-novo mutations in LMNA, the gene encoding prelamin A. LÄS MER