Sökning: "MPD"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet MPD.

  1. 1. Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer

    Författare :Annika Wahlström; Göteborgs universitet; []
    Nyckelord :RCE1; ICMT; K-RAS; CAAX proteins; MPD; lung cancer;

    Sammanfattning : CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) of the CAAX motif by farnesyltransferase (FTase) or geranylgeranyltransferase-I (GGTase-I); second, the –AAX are removed by RAS converting enzyme 1 (RCE1); and third, the cysteine is methylated by isoprenylcysteine carboxyl methyltransferase (ICMT). LÄS MER

  3. 2. Targeting NOX2 in cancer

    Författare :Ebru Aydin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; reactive oxygen species; immunotherapy; nox2; nk cells; melanoma; histamine; metastasis; leukemia; aml; cml; kras; mpd;

    Sammanfattning : Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. LÄS MER

  4. 3. Clinical and experimental studies in Philadelphia chromosome negative chronic myeloproliferative disorders

    Författare :Peter Johansson; Göteborgs universitet; []
    Nyckelord :myeloproliferative disorders; polycythaemia vera; essential thrombocythaemia; epidemiology; erythropoietin; red-cell mass; spleen size; thrombo-embolic; PRV-1.;

    Sammanfattning : The present thesis deals with various aspects on the (a) epidemiology, (b) diagnosis, and (c) molecular biology in Philadelphia chromosome negative (Ph-) chronic myeloproliferative disorders (MPD). First, the incidence of the three Ph- MPD, polycythaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF) was investigated in the city of Göteborg, Sweden during the years 1983-1999 (Paper I). LÄS MER

  5. 4. Improvement of the diagnosis and management of cystic tumors of the pancreas

    Författare :Zeeshan Ateeb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pancreatic cancer is on its course on becoming the second cause of cancer related mortality. Although improvements have been made in the treatment arsenal, still only a minority of patients are able to receive treatment with curative intention. LÄS MER

  7. 5. PEG and lipids in solid dispersions and liquid crystals - structure and phase behaviour

    Författare :Johan Unga; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bicontinuous sponge phase; polyethylene glycol; monoolein; bicontinuous cubic phase; lipids; differential scanning calorimetry; phytantriol; small angle X-ray diffraction; solid dispersions;

    Sammanfattning : In this thesis, two different kinds of nano-structured systems have been studied; solid dispersion systems of polyethylene glycol (PEG) and liquid crystalline systems containing the polar lipids monoolein (MO) and phytantriol (PT). Solid dispersions of PEG were studied with addition of different substances, lipids or parabens. LÄS MER