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Hittade 2 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Molecular factors relevant to the radiosensitivity of human tumours

   Författare :Anya Polischouk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :c-Ha-ras; c-myc; radiosensitivity; DNA double-strand break repair; DNA singlestrand repair;

   Sammanfattning : Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC oncogenes were analysed in 70 biopsies and 51 blood samples from the same patients and compared with RS estimated by the clinical tumour response and by response to irradiation of tumour samples using subrenal capsule assay. LÄS MER

3. 2. Modulation of activity of the tumour suppressor p53 by small molecules and damaged DNA

   Författare :Marina Protopopova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The p53 is a potent tumor suppressor, which becomes activated in response to stress. The activated p53 triggers a cell cycle arrest in GI or apoptosis, ensuring a suppression of a tumor development by the elimination of cells carrying potentially tumorigenic lesions. LÄS MER