Sökning: "DNA ploidy"

Visar resultat 16 - 20 av 44 avhandlingar innehållade orden DNA ploidy.

1. 16. Genomic changes defining the progression of human colorectal and cervical tumors

   Författare :Kerstin Heselmeyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :colorectal; cervical; anal neoplasias proliferation; DNA ploidy; p53 and p21WAF1 expression; HPV; CGH;

   Sammanfattning : Defining changes during the carcinogenesis and progression of tumors is a major way to obtain a better understanding of the mechanisms of cancer development. We therefore investigated the carcinogenesis process in the colon-rectum and in the uterine cervix by different cell chemical, immunohistochemical and cytogenetic methods. LÄS MER

3. 17. Assessment of diagnostic and prognostic factors in pancreatic duct carcinoma

   Författare :Stefan Linder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Pancreatic neoplasms; cytology; diagnosis; prognosis; DNA ploidy; morphometry; immunohistochemistry; Ki-67 antigen; p53 protein; ECM proteins; adhesion molecules.;

   Sammanfattning : The diagnosis pancreatic carcinoma is suggested by a combination of clinical and radiological signs. The differential diagnosis vs. chronic pancreatitis may, however, be difficult. Morphological verification of malignancy is therefore necessary before initiating non-surgical therapy. LÄS MER

4. 18. Quantitative cellular methods in the evaluation of prostate cancer

   Författare :Naining Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :prostate cancer; histopathology; nuclear morphology; DNA ploidy; S-phase fraction; thymidine kinas; Ki-67; cell proliferation; fluorescence cytometry; tissue PSA; prognosis;

   Sammanfattning : The distinction between those prostate cancers rapidly progressing and leading to death and those with little likelihood of causing death in cancer is a major goal in current prostate cancer research. Morphological tumor characteristics at present are the basis for evaluation of the prognosis of the disease. LÄS MER

5. 19. Primary fallopian tube cancer

   Författare :Ann-Cathrin Hellström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :primary fallopian tube cancer; prognosis; symtoms; treatment; staging; DNA ploidy; cell proliferation; tumor angiogenesis; p53; p21WAF I expression; HPV; CGH; PCRSSCP; CDGE;

   Sammanfattning : Primary fallopian tube cancer (PFTC) is a rare and aggressive gynecologic malignancy and it accounts for less than 5% of all genital female cancers according to the Swedish Cancer Registry. In a retrospective study we have analysed histopathological, clinical, biological and prognostic factors among patients with PFTC. LÄS MER

7. 20. Clinical fluorescence cytometry : improvements to preparation methods and instrumentation

   Författare :Thomas Heiden; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Fluorescence analysis; flow cytometry; image cytometry; DNA ploidy; proliferation; apoptosis; paraffin-embedded tissues; fresh tissues; S-phase fraction; debris; aggregates; spectral overlap; wavelength switching;

   Sammanfattning : Fluorescence cytometry, which can be carried out by flow or image cytometry (FCM, ICM), provides a highly sensitive and specific tool for quantitative analysis of cell material. It is emerging from being a pure research method and becoming an important adjunct to clinical practice. To better realize its potential, more research is needed. LÄS MER