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Visar resultat 21 - 25 av 43 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Skeletal muscle PGC-1α1 and KAT enzymes at the intersection between depression and metabolic disease

    Författare :Leandro Z Agudelo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression and metabolic diseases are leading causes of disability and major contributors to socioeconomic burden worldwide. Physical activity exerts many beneficial effects that confer direct health improvement in individuals suffering from these disorders. LÄS MER

  3. 22. Targeting chronic lymphocytic leukemia cells using anti-ROR1 monoclonal antibodies and small molecules inhibitors

    Författare :Salam Khan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) is characterized by accumulation of malignant B cells in blood, bone marrow, spleen and lymph nodes. It is the most common leukemia in the Western world. Major progress has been made in recent years to prolong the survival and improve the well-being of the patients. LÄS MER

  4. 23. Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells

    Författare :Lisa Meijer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipopolysaccharide (LPS) is a well-characterized pathogen-associated molecule found primarily as a constituent of the outer membrane of Gram-negative bacteria. LPS is known to act on different cell types in a pleiotropic manner. LÄS MER

  5. 24. Calcium signaling in development and disease

    Författare :Marie Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The calcium ion (Ca2+) is a highly versatile signaling messenger involved in a diverse range of physiological processes such as gene transcription/expression, proliferation, differentiation and cell death. Intracellular Ca2+ signals are generated through a 10 000 – 20 000 fold gradient across the cell membrane and via release from the external milieu and/or internal Ca2+ stores. LÄS MER

  7. 25. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function

    Författare :Alexander Balhuizen; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Estrogen; Serotonin; Pancreatic islets; Insulin resistance; Beta-cell function; GPCR;

    Sammanfattning : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). LÄS MER