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1. 1. Mutation profile at the hprt locus in T-cells of non-smoking males

   Författare :Anne-May Österholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :human T-cells; hprt mutation; in vivo; deletion; splicing; base substitution;

   Sammanfattning : Extensive studies have been done on mutations in several marker genes in order to predict health consequences such as carcinogenesis. However, more information about mutations arising in vivo in somatic cells is needed to understand the relationship between the different factors involved in mutagenesis such as DNA damage, DNA repair capacity and individual susceptibility, and to elucidate the influence of endogenous mechanisms and environmental exposures. LÄS MER