Sökning: "vetenskaplig artikel diabetes"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden vetenskaplig artikel diabetes.

1. 1. Dissecting the role of micro-RNAs in diabetes

   Författare :Caroline Bolmeson; Create Health; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

   Sammanfattning : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. LÄS MER

3. 2. Antigen-specific islet antibodies: prediction of beta cell failure and differentiation between Type 1 and Type 2 diabetes

   Författare :Henrik Borg; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; secreting systems; Endocrinology; seropositive; seronegative; slowly-progressive; Type 2; Type 1; classification; IA-2A; IA-2; GADA; GAD; ICA; islet antibodies; C-peptide; beta cell function; diabetes mellitus; adult-onset; sekretion; diabetologi;

   Sammanfattning : Autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine-phosphatase-like protein (IAÐ2A), and/or pancreatic islet cells (ICA) are autoimmune markers usually present at diagnosis of Type 1 diabetes. Type 1 diabetes is therefore in general believed to be caused by an immune-mediated beta cell destruction. LÄS MER

4. 3. Common variants in genes regulating free fatty acid metabolism and risk of type 2 diabetes and cardiovascular disease

   Författare :Martin Carlsson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; free fatty acids; genetics; UCP1; beta3-adrenergic receptor; beta2-adrenergic receptor; type 2 diabetes mellitus; FABP2; stroke; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Abstract The present study evaluated genetic and metabolic factors influencing the risk for type 2 diabetes and cardiovascular disease (CVD) with special reference to increased concentrations of free fatty acids (FFA) in 1174 Swedish diabetic and nondiabetic subjects. Common polymorphisms in the fatty acid binding protein 2 (FABP2), the B2-adrenergic receptor (B2-AR), the B3 -adrenergic receptor (B3-AR) and the uncoupling protein 1 (UCP-1) genes were related to anthropometric and metabolic variables. LÄS MER

5. 4. GABA in the islets of Langerhans

   Författare :Anna Wendt; Diabetes - öcellsexocytos; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; diabetologi; sekretion; Endokrinologi; Endocrinology; SLMV; paracrine regulation; LDCV; islets of Langerhans; autocrine regulation; GABA; diabetology;

   Sammanfattning : GABA (γ-aminobutyric acid) is a well-known inhibitory neurotransmitter in the CNS. GABA is also present at high concentrations in the insulin-producing β-cells in the islets of Langerhans, but its function there is less clear. GABA is believed to accumulate in SLMVs (synaptic-like microvesicles). LÄS MER

7. 5. Metabolic Effects of Growth Hormone Replacement Therapy in Adults - with Special Reference to Insulin Sensitivity

   Författare :Mikael Segerlantz; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; Endokrinologi; sekretion; diabetologi; cortisol replacement; lipid oxidation; glucose metabolism; glucose uptake; insulin resitance; GH; insulin sensitivity; GH deficiency;

   Sammanfattning : A risk for premature atherosclerosis and increased cardiovascular mortality has been reported in adult patients suffering from growth hormone deficiency (GHD) and receiving conventional hormone substitution without growth hormone (GH) replacement. GHD patients are resistant to insulin, which is a potential risk factor for cardiovascular mortality. LÄS MER