Sökning: "autocrine regulation"
Visar resultat 1 - 5 av 58 avhandlingar innehållade orden autocrine regulation.
1. ADP regulation of insulin secretion and beta-cell apoptosis
Sammanfattning : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. LÄS MER
2. GABA in the islets of Langerhans
Sammanfattning : GABA (γ-aminobutyric acid) is a well-known inhibitory neurotransmitter in the CNS. GABA is also present at high concentrations in the insulin-producing β-cells in the islets of Langerhans, but its function there is less clear. GABA is believed to accumulate in SLMVs (synaptic-like microvesicles). LÄS MER
3. Growth regulation in sarcomas : studies in vivo and in cell culture
Sammanfattning : Sarcomas are malignant tumors of mesenchymal origin, and can arise in soft-tissue and in bones. It has been suggested that the abnormal growth regulation in sarcoma cells may be due to an autocrine mechanism, in which the cells are stimulated by an endogenous production of growth factors. LÄS MER
4. Impact of autocrine factors on physiology and productivity in Trichoplusia ni serum-free cultures
Sammanfattning : The aim of this study was to increase the understanding of the mechanisms regulating cell proliferation and recombinant protein production in serum-free cultures of Trichoplusia ni (T. ni) insect cells.Conditioned medium (CM) was shown to contain both stimulatory and inhibitory factors (CM factors) influencing cell growth. LÄS MER
5. Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
Sammanfattning : The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. LÄS MER