Sökning: "triggers"

Visar resultat 21 - 25 av 384 avhandlingar innehållade ordet triggers.

  1. 21. Effects of direct oral anticoagulant treatment on hemostasis in patients with atrial fibrillation

    Författare :Viktor Schutz Taune; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The direct oral anticoagulants (DOAC) – dabigatran, rivaroxaban, apixaban and edoxaban – were approved without the need for routine monitoring. However, in parallel with clinical implementation, studies on how to measure the effect of DOACs have become a research area of increasing interest during the last decade. LÄS MER

  3. 22. Cellular and molecular mechanisms of ischemic brain damage in hyperglycemic rats

    Författare :Hiroyuki Uchino; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Reperfusion injury; Mitochondria; Permeability transition; Cyclosporin A; Neurotrophins; Seizures; Brain damage; Acidosis; Hypercapnia; Ischemia; Hyperglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The present study is centered on mechanisms of ischemic brain damage in hyperglycemic animals, and in those in which exaggerated intraischemic acidosis was induced by superimposed hypercapnia in normoglycemic animals. The initial experiments were focussed on the pathophysiology of postischemic seizures. LÄS MER

  4. 23. The road from atherosclerosis to myocardial infarction : studies in an experimental model

    Författare :Anne-Louise Hemdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; myocardial infarction; ischemia; hypoxia; matrix metalloproteinase; remodelling; electrocardiogram; gene expression; inflammation;

    Sammanfattning : Atherosclerosis is a slow progressing disease with continuous lipid deposition and inflammation in the arterial wall. Stenotic arteries may cause angina pectoris but it is the sudden formation of an occluding thrombosis on the atherosclerotic plaque that leads to myocardial infarction. LÄS MER

  5. 24. Pathogenesis of arthritis in rats : genetic factors and inducing molecules

    Författare :Johnny C Lorentzen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :arthritis; adjuvants; autoimmunity; MHC; genetics; rat; cytokines;

    Sammanfattning : Rheumatoid Arthritis (RA) is a chronic joint disease for which there is presently no cure, possibly because rational design of therapy is hindered by lack of knowledge of disease mechanisms (pathogenesis), and disease causing genetic and inducing factors (etiology). In this thesis, etiopathogenetic clues were sought in experimental arthritis, induced in different rat strains using both specific and nonspecific triggers of the immune system, i. LÄS MER

  7. 25. Pathophysiological regulation of white adipocyte exocytosis of different adiponectin molecular forms

    Författare :Musovic Saliha; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; White adipocytes; adiponectin exocytosis secretion; health and metabolic disease;

    Sammanfattning : In this thesis we have identified mechanisms involved in the exocytosis of different adiponectin molecular forms in health and in metabolic disease. We have also studied similarities and differences in depot-specific adipocyte adiponectin release. LÄS MER