Sökning: "trifluoromethylation"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet trifluoromethylation.

1. 1. Oxidative Trifluoromethylation and other Functionalization Reactions of Alkenes and Alkynes

   Författare :Pär Janson; Kálmán Szabó; Antonio Togni; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; transition metal; trifluoromethylation; catalysis; acetoxylation; difunctionalization; oxidation; mechanistic study; alkenes; alkynes; quinones; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis concerns the use of various potent oxidants in organic synthesis. The main focus is directed at selectively introducing trifluoromethyl groups into compounds containing double or triple bonds. All reactions proceed under mild conditions and can in most cases be performed on the bench-top. LÄS MER

3. 2. Novel Applications of Benziodoxole Reagents in the Synthesis of Organofluorine Compounds

   Författare :Nadia O. Ilchenko; Kálmán J. Szabó; Cristina Nevado; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; trifluoromethylation; hypervalent iodine; Togni reagent; difluorination; iodofluorination; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis concerns method development of new synthetic routes by applying electrophilic hypervalent iodine reagents, such as trifluoromethyl-benziodoxole (Togni reagent) and fluoro-benziodoxole. The first project involved the addition of an oxygen moiety and trifluoromethyl group across double and triple bonds (both groups derived from the hypervalent iodine reagent). LÄS MER

4. 3. Synthesis of functionalized allylic, propargylic and allenylic compounds : Selective formation of C–B, C–C, C–CF3 and C-Si bonds

   Författare :Tony Zhao; Kálmán Szabó; Hajime Ito; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium catalysis; allylboration; allenylboration; trifluoromethylation; silylation; copper catalysis; borylation; bimetallic catalysis; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis is focused on the development of new palladium and copper- mediated reactions for functionalization of alkenes and propargylic alcohol derivatives. The synthetic utility of the 1,2-diborylated butadienes synthesized in one of these processes has also been demonstrated. LÄS MER

5. 4. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations

   Författare :Johanna M. Larsson; Kálmán J. Szabó; Dennis G. Hall; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; catalysis; Heck reaction; C-H functionalization; allylic substitution; silylation; borylation; trifluoromethylation; fluorination; mechanistic study; transition metal; alkene; allylic silane; allylic boronate; allylic fluoride; organisk kemi; Organic Chemistry;

   Sammanfattning : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. LÄS MER

7. 5. Transformations of Nitrosoarenes and Alkynyl Enones : Selective Synthesis of Nitrogen-Containing Compounds

   Författare :Angela van der Werf; Nicklas Selander; Gary A. Molander; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alkynyl enones; catalysis; copper; halogenation; heterocycles; nitrosoarenes; perfluoroalkylation; trifluoromethylation; organisk kemi; Organic Chemistry;

   Sammanfattning : The nitrogen atom plays a unique role in organic chemistry. It is abundantly found in organic materials and is responsible for the activity of many biologically relevant compounds. LÄS MER