Sökning: "synthetic method development"

Visar resultat 1 - 5 av 155 avhandlingar innehållade orden synthetic method development.

  1. 1. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations

    Författare :Johanna M. Larsson; Kálmán J. Szabó; Dennis G. Hall; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; catalysis; Heck reaction; C-H functionalization; allylic substitution; silylation; borylation; trifluoromethylation; fluorination; mechanistic study; transition metal; alkene; allylic silane; allylic boronate; allylic fluoride; organisk kemi; Organic Chemistry;

    Sammanfattning : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. LÄS MER

  3. 2. Lanthanide-mediated C-F Bond Activation Method Development and Mechanistic Investigation

    Författare :Mario Janjetovic; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; C-F bond activation; fluorine chemistry; lanthanides; single-electron transfer reagent; Lewis acid; chemoselectivity; synthetic method; catalysis;

    Sammanfattning : The use of transition-metals and main-group Lewis acids has proven to be an outstanding source for activation and subsequent functionalization of fluorinated compounds. However, the first is mainly limited to C(sp2)–F bonds which partially are activated by an adjacent heteroatom, and the latter is limited to simple C(sp3)–F bonds due to particularly strong Lewis acid character. LÄS MER

  4. 3. A Chemical Approach Toward the Therapeutic Optimization of Cytotoxic Bioconjugates

    Författare :Rafael Hartmann; Luke R. Odell; Fredrik Lehmann; Mats Larhed; Dario Neri; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; antibody-drug conjugates; organic synthesis; bioorganic chemistry; synthetic method development; analytical method development; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi; Medicinal Chemistry; Läkemedelskemi; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : The delivery of cytotoxicity to specific cells was recognized to be the key to the effective, chemical treatment of infectious and neoplastic diseases well over a century ago. In the context of oncology, the primary therapeutic challenge is the distinction between healthy and pathological cells despite their pronounced pheno- and genotypic similarity. LÄS MER

  5. 4. Metal release from powder particles in synthetic biological media

    Författare :Klara Midander; Jinshan Pan; Mats Norell; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; metal release; stainless steel; Cu; powder particles; synthetic body fluids; test method; in vitro tests; Other materials science; Övrig teknisk materialvetenskap;

    Sammanfattning : Humans are exposed to metals and metal-containing materials daily, either conscious, e.g. using metal tools or objects, or unconscious, e.g. LÄS MER

  7. 5. Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates

    Författare :Marcin Bielawski; Berit Olofsson; Antonio Togni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hypervalent Iodine Compounds; One-Pot Synthesis; Regiospecific Synthesis; Aromatic Substitution; Aryl Iodides; Arenes; Boronic Acids; Heteroaromatics; Arylations; Reaction Mechanisms; Density Functional Calculations; Large Scale Synthesis; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts.  The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. LÄS MER