Sökning: "solid-phase synthesis"

Visar resultat 21 - 25 av 82 avhandlingar innehållade orden solid-phase synthesis.

  1. 21. Design, Synthesis and Characterization of Small Molecule Inhibitors and Small Molecule : Peptide Conjugates as Protein Actors

    Författare :Jonas Nilsson; Lars Baltzer; Ingemar Kvarnström; Thomas Olsson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synthetic receptor; Peptide inhibitor conjugate; Peptide protein surface interactions; General Lead Discovery Library; Combinatorial Chemistry; Solid Phase Chemistry; Targeted Library; Thrombin inhibitor; Fluorescence; Surface Plasmon Resonance; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis describes different aspects of protein interactions. Initially the function of peptides and their conjugates with small molecule inhibitors on the surface of Human Carbonic Anhydrase isoenzyme II (HCAII) is evaluated. LÄS MER

  3. 22. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    Författare :Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; Organic synthesis; Organisk syntes;

    Sammanfattning : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. LÄS MER

  4. 23. Chemical Engineering of Small Affinity Proteins

    Författare :Joel Lindgren; Amelie Eriksson Karlström; Lars Baltzer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; albumin binding domain; ligation; protein synthesis; solid phase peptide synthesis; Bioteknologi; Biotechnology;

    Sammanfattning : Small robust affinity proteins have shown great potential for use in therapy, in vivo diagnostics, and various biotechnological applications. However, the affinity proteins often need to be modified or functionalized to be successful in many of these applications. LÄS MER

  5. 24. Strategies for developing peptide and protein selective plastic antibodies

    Författare :Rashmi Mahajan; Ian A. Nicholls; Subramanian Suriyanarayanan; Börje Sellergren; Alessandra Maria Bossi; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Competitive assays; molecularly imprinted polymer; magnetic nanoparticle; nanogel; nanoparticle; plastic antibody; solid-phase synthesis; QCM.; Biokemi; Biochemistry;

    Sammanfattning : The objective of the thesis was to explore approaches for the development of molecularly imprinted materials with predetermined selectivity for peptide or protein targets. In particular, the work has focused on molecularly imprinted nanoparticles synthesized using solid-phase synthesis protocols. LÄS MER

  7. 25. Functional Copolymers of Polyvinylpyrrolidone

    Författare :Jonas Engström; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; suspension polymerization; functional monomers; 1-vinylpyrrolidin-2-one; copolymerization; swelling; crosslinking; solid-phase synthesis; drug delivery vehicles.; phase-selective solubility; beads; Polyvinylpyrrolidone;

    Sammanfattning : In many ways, polyvinylpyrrolidone (PVP) has a unique combination of chemical and physical properties. Unlike most polymers it is soluble in water as well as a number of organic solvents. PVP also has excellent film forming properties, outstanding chemical stability, complexing ability, low toxicity, and good adherence to many different substrates. LÄS MER