Sökning: "slow progression"

Visar resultat 1 - 5 av 84 avhandlingar innehållade orden slow progression.

  1. 1. Slow progression in HIV-1 infection : clinical, virological and immunological study

    Författare :Christina Broström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; PHI; prognosis; slow progression; LTNP; longitudinal; specific pattern; HIV-1 RNA; HIV-1 DNA; spontaneous decrease;

    Sammanfattning : The aim of the present thesis was to study factors that could possibly influence the course of HIV-1 infection with special emphasis on slow progression of the disease. Clinical, virological and immunological parameters were evaluated. One important clinical factor for the outcome of HIV-1 infection was identified. LÄS MER

  3. 2. Viral parameters influencing clinical long-term non progression in HIV-1 infected subjects

    Författare :Ubaldo Visco Comandini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :LTNP; HIV-1 DNA; HIV-1 RNA; quantification; spontaneous decrease; genetic heterogeneity; nef; LTR; CCR5 deletion;

    Sammanfattning : A very small portion of the HIV-1 infected population is constituted by individuals, called long- term non progressors (LTNP), in whom after even a decade or more, no visible deterioration of the immune system is recognized and the infection remains therefore asymptomatic. The reasons for such "natural" prolonged well-being can be attributed to both the virus and the infected host and their understanding is likely to give important information for the development of an effective HIV- vaccine and for immune reconstitution therapy. LÄS MER

  4. 3. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults

    Författare :Åsa Björndal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1 HIV-2 biological phenotype genetic subtype chemokine receptors disease progression monocyte-derived macrophages;

    Sammanfattning : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. LÄS MER

  5. 4. HIV disease progression - Impact of HIV-1 intersubtype recombination and association with HIV-2 evolution

    Författare :Angelica Palm; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are both causative agents of AIDS, with similar pathogenic characteristics. However, the rate of disease progression is highly variable both within and between HIV-1 and HIV 2, but the mechanisms involved in modulating the rate of disease progression remain poorly understood. LÄS MER

  7. 5. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression

    Författare :Fredrik Johansson; Bengt Westermark; Leif Carlsson; Uppsala universitet; []
    Nyckelord :Pathology; PDGF; insertional mutagenesis; retroviral tagging; common insertion site; glioma; expression; cGMP-dependent protein kinase II; Patologi;

    Sammanfattning : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. LÄS MER