Sökning: "Bengt Westermark"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Bengt Westermark.

  1. 1. Growth control of normal and neoplastic human glia-like cells in culture

    Författare :Bengt Westermark; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Investigations of Proneural Glioblastoma to Identify Novel Therapeutic Targets

    Författare :Maria Boije; Lene Uhrbom; Bengt Westermark; Rolf Bjerkvig; Uppsala universitet; []
    Nyckelord :Glioma; proneural subtype; hallmarks; glioma initiating cells; S-SOX5; angiogenesis; stromal cells; Tumour biology; Tumörbiologi; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Malignant glioma is a highly lethal and destructive disease with no proper cure. We have investigated some of the hallmarks of cancer in connection to glioma and found ways to disrupt these and prevent tumor growth. The work is done within the context of a glioma subtype distinguished by activation of PDGF signaling termed the proneural subtype. LÄS MER

  4. 3. Molecular and Cellular Complexity of Glioma : Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

    Författare :Demet Çağlayan; Bengt Westermark; Maria Ferletta; Ana Martin-Villalba; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

    Sammanfattning : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. LÄS MER

  5. 4. Glioblastoma heterogeneity and plasticity : Investigating the roles of BMP4 and SOX2

    Författare :Erika Dalmo; Bengt Westermark; Fredrik J. Swartling; Lene Uhrbom; Ana Martin-Villalba; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; SOX2; BMP4; senescence; plasticity; Oncology; Onkologi; Medicinsk vetenskap; Medical Science; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The malignant primary brain tumor glioblastoma has a dismal prognosis and is distinguished by its heterogeneous character. Current treatment with surgical resection, radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide does not provide a cure, but simply prolongs survival by a few months. LÄS MER

  7. 5. Roles of PDGF for Neural Stem Cells

    Författare :Mia Enarsson; Karin Nilsson; Bengt Westermark; Peter Eriksson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; CNS; stem cells; neuron; PDGF; proliferation; differentiation; ERK; microarray; transgenic mouse; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Stem cells are endowed with unique qualities: they can both self-renew and give rise to new mature cell types. Central nervous system (CNS) stem cells can give rise to neurons and glia. LÄS MER