Sökning: "remodelling"

Visar resultat 11 - 15 av 200 avhandlingar innehållade ordet remodelling.

  1. 11. Integration of signalling in smooth muscle caveolae

    Författare :Yulia Shakirova; Cellulär biomekanik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Caveola; caveolin; detrusor; cavin; smooth muscle contractility; remodelling; NO; vascular dysfunction; smooth muscle; erectile dysfunction;

    Sammanfattning : Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. LÄS MER

  3. 12. Vascular remodelling and circulating basement membrane fragments in abdominal aortic aneurysm

    Författare :Mari Holsti; Malin Sund; Anders Wanhainen; Joakim Nordanstig; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AAA; extracellular matrix; vascular remodelling; collagen; inflammation; Surgery; kirurgi;

    Sammanfattning : An abdominal aortic aneurysm (AAA) is a degenerative disease, characterized by advanced inflammation and extracellular matrix (ECM) remodelling. Enhanced protease activity mediated by cytokines results in the degradation of ECM proteins, leading to the generation of different bioactive fragments. LÄS MER

  4. 13. Platelets and eosinophils in lung tissue remodelling

    Författare :Ulrika Zagai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :eosinophil; fibroblast; inflammation; lung; platelet; remodelling;

    Sammanfattning : Tissue injury and inflammation followed by effective repair restores normal function, but defective repair with associated tissue remodelling and fibrosis can lead to loss of organ function. Thus, interactions between inflammatory and mesenchymal cells in connection with the remodelling processes are of considerable importance with regards to the development of pulmonary disorders, since this interplay determines the outcome of the disease. LÄS MER

  5. 14. Regulation of RNA polymerase I and RNA polymerase III transcription by the chromatin remodelling complex B-WICH

    Författare :Fatemeh Sadeghifar; Ann-Kristin Östlund Farrants; Magdalena Boguta; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; B-WICH; Chromatin remodelling; ribosomal genes; transcription; Cell Biology; cellbiologi;

    Sammanfattning : Ribosomal biogenesis is an important process which determines the rate of cell growth and is involved in cell response to proliferation, differentiation, cellular nutritional state and stress. The chromatin remodelling complex B-WICH composed of WSTF, SNF2h and NM1 is involved in transcription by the RNA pol I and RNA pol III. LÄS MER

  7. 15. Novel Insights into Inflammatory Disturbed Bone Remodelling

    Författare :Elin Kindstedt; Pernilla Lundberg; Östen Ljunggren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone; osteoblast; osteoclast; chemokines; CCL11; periodontitis; rheumatoid arthritis; innate lympoid cells; odontologi; Odontology; immunologi; Immunology; biology; biologi; reumatologi; rheumatology;

    Sammanfattning : Bone is a dynamic tissue that is continuously remodelled, a process that requires equal amounts of osteoclastic bone resorption and osteoblastic bone formation. Inflammation may disturb the equilibrium and result in local and/or systemic bone loss. Negative bone mass balance occurs in several chronic inflammatory diseases, e.g. LÄS MER