Sökning: "protein oligomerization"

Visar resultat 11 - 15 av 58 avhandlingar innehållade orden protein oligomerization.

  1. 11. The Design and Structure Prediction of Protein Oligomers

    Författare :Robert Lizatovic; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

    Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER

  3. 12. The complex world of proteins: Structure, function, and oligomerization of frataxin

    Författare :Christopher Söderberg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Frataxin; Friedreich s ataxia; self-assembly; protein-protein interaction; iron homeostasis; SAXS; cross-linking;

    Sammanfattning : Patients suffering from the deadly progressive neurodegenerative disease Friedreich's ataxia have reduced levels of expression of the protein frataxin. Yeast frataxin has been extensively studied in vitro, and has been shown to deliver iron to heme and iron-sulfur cluster biosynthesis, as well as to oligomerize in the presence of iron. LÄS MER

  4. 13. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

    Författare :Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

    Sammanfattning : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. LÄS MER

  5. 14. NA transmembrane domain : Amphiphilic drift to accommodate two functions

    Författare :Johan Nordholm; Robert Daniels; Ervin Fodor; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; influenza; IAV; neuraminidase; NA; transmembrane domain; TMD; secretory protein; ER-targeting sequence; ER-targeting sequence coding region; protein regulation; NS1; GALLEX; Biochemistry; biokemi;

    Sammanfattning : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. LÄS MER

  7. 15. The Biophysics of Na+,K+-ATPase in neuronal health and disease

    Författare :Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

    Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER