Sökning: "protein-protein interaction"

Visar resultat 1 - 5 av 138 avhandlingar innehållade orden protein-protein interaction.

1. 1. Protein-Protein Interactions in Human Aquaporin Regulation

   Författare :Jennifer Virginia Roche; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; Human Aquaporins; water channels; Protein-protein interaction; Regulation; AQP2; AQP0; LIP5; CaM;

   Sammanfattning : Water is an essential compoment of every living orgamism and forms a major part of the human body. Regulated water transport is crucial for proper cell functioning and body homeostasis. LÄS MER

3. 2. Biophysical characterization of protein-protein interactions involving intrinsically disordered proteins

   Författare :Ida Nyqvist; Jakob Dogan; Ivarsson Ylva; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Intrinsically disordered proteins; Protein-protein interactions; Disorder-to-order transition; Rate-limiting transition state; Ф-value analysis; NMR relaxation; Side-chain dynamics; Backbone dynamics; Conformational entropy change; Biophysics; biofysik;

   Sammanfattning : Intrinsically disordered proteins and regions (IDPs/Rs) are proteins that do not form stable and well-defined structures in their free states but rather occupy an ensemble of conformations that change over time while still staying functional. They are prevalent in the eukaryotic proteome and are involved in various vital processes in the cell where they often interact with their binding partners through coupled binding and folding reactions. LÄS MER

4. 3. Molecular principles of protein stability and protein-protein interactions

   Författare :Christofer Lendel; Per-Åke Nygren; Christopher M. Dobson; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.; Structural biochemistry; Strukturbiokemi;

   Sammanfattning : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. LÄS MER

5. 4. Protein-protein interactions in model systems : design, control of catalytic activity and biosensor applications

   Författare :Johan Rydberg; Lars Baltzer; Joel Schneider; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Protein interactions; design; catalysis; biosensors; hybride materials; nanoparticles; Kemi; Chemistry; Kemi;

   Sammanfattning : This thesis describes the design of polypeptides, unordered in the monomeric state but capable of folding into helix-loop-helix motifs and dimerise to form four-helix bundles. The goal of the design was to encode them with the capacity to form dimers highly selectively and the ability to carry out molecular functions in the folded state but not in the unordered state, and thus to establish a molecular link between recognition and function. LÄS MER

7. 5. Exploration of analytical methods to study motif-mediated host-virus protein-protein interactions

   Författare :Eszter Kassa; Ylva Ivarsson; Gilles Travé; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein-protein interaction; short linear motif; affinity purification-mass spectrometry; virus; SARS-CoV-2; TBEV; Analytical Chemistry; Analytisk kemi;

   Sammanfattning : Proteins are responsible for countless processes in living creatures, but most often they do not perform these tasks alone. Rather, they engage in interactions with other proteins, creating whole protein-protein interaction (PPI) networks. LÄS MER