Sökning: "pppGpp"

Hittade 5 avhandlingar innehållade ordet pppGpp.

1. 1. The ribosome, stringent factor and the bacterial stringent response

   Författare :Rose-Marie Jenvert; Lovisa Holmberg Schiavone; Suparna Sanyal; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; stringent factor; stringent response; tRNA; ribosomal protein L11; pppGpp; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

   Sammanfattning : The stringent response plays a significant role in the survival of bacteria during different environmental conditions. It is activated by the binding of stringent factor (SF) to stalled ribosomes that have an unacylated tRNA in the ribosomal A-site which leads to the synthesis of (p)ppGpp. LÄS MER

3. 2. Dynamics in Protein Synthesis, Structural Studies of Translation Factors

   Författare :Martin Laurberg; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Flexibility; Fusidic Acid; tRNA; Translation Factors; Ribosome; Molekylär biofysik;

   Sammanfattning : Protein biosynthesis is performed on ribosomes. The ribosome is a complex of ribosomal RNA and proteins forming two subunits. A messenger RNA strand is decoded on the small subunit by charged aminoacyl transfer RNA (aa-tRNA) molecules and each tRNA molecule delivers its amino acid to the growing polypeptide chain on the large subunit. LÄS MER

4. 3. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

   Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

   Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER

5. 4. Functional studies of Escherichia coli stringent response factor RelA

   Författare :Ievgen Dzhygyr; Vasili Hauryliuk; Jörgen Johansson; Greg Bokinsky; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stringent response; RelA; p ppGpp; ribosome; tRNA; metabolism regulation; allosteric regulation; translation; nutritional stress; molekylärbiologi; Molecular Biology;

   Sammanfattning : RelA is a ribosome associated multi-domain enzyme, which plays a crucial role in adaptation ofEscherichia coli to nutritional stress as such as amino acid deficiency. It detects the deficiency of aminoacids in the cell by monitoring whether a tRNA at the acceptor site (A-site) of the ribosome is chargedwith amino acid or not. LÄS MER

7. 5. Bioinformatics, evolution and revolution in our understanding of toxin-antitoxin systems

   Författare :Chayan Kumar Saha; Gemma C. Atkinson; Victoria Shingler; Gipsi Lima Mendez; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Alarmones; Evolution; Gene neighbourhood; Toxin; Antitoxin; molekylärbiologi; Molecular Biology;

   Sammanfattning : Bacteria experience a wide range of natural challenges during their life cycles, to which they must respond and adapt to live. Under stressed conditions such as amino acid starvation, bacteria slow down their growth mechanism by producing small alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp. LÄS MER