Sökning: "Vasili Hauryliuk"

Hittade 3 avhandlingar innehållade orden Vasili Hauryliuk.

  1. 1. A Few Strokes to the Family Portrait of Translational GTPases

    Författare :Vasili Hauryliuk; Måns Ehrenberg; Richard Buckingham; Uppsala universitet; []
    Nyckelord :Molecular biology; translation; GTPase; EF-G; eRF3; Molekylärbiologi;

    Sammanfattning : Protein biosynthesis is a core process in all living organisms. Assembly of the protein chain from aminoacids is catalysed by the ribosome, ancient and extremely complex macromolecular machine. LÄS MER

  3. 2. Functional studies of Escherichia coli stringent response factor RelA

    Författare :Ievgen Dzhygyr; Vasili Hauryliuk; Jörgen Johansson; Greg Bokinsky; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stringent response; RelA; p ppGpp; ribosome; tRNA; metabolism regulation; allosteric regulation; translation; nutritional stress; molekylärbiologi; Molecular Biology;

    Sammanfattning : RelA is a ribosome associated multi-domain enzyme, which plays a crucial role in adaptation ofEscherichia coli to nutritional stress as such as amino acid deficiency. It detects the deficiency of aminoacids in the cell by monitoring whether a tRNA at the acceptor site (A-site) of the ribosome is chargedwith amino acid or not. LÄS MER

  4. 3. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

    Författare :Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

    Sammanfattning : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. LÄS MER