Sökning: "Suparna Sanyal"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Suparna Sanyal.

  1. 1. Elongation factor 2: A key component of the translation machinery in eukaryotes : Properties of yeast elongation factor 2 studied in vivo

    Författare :Galyna Bartish; Odd Nygård; Suparna Sanyal; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Elongation factor 2; yeast; ribosome; phosphorylation; Switch I; site-directed mutagenesis; functional complementation; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

    Sammanfattning : Synthesis of proteins is performed by the ribosome, a large ribonucleoprotein complex. Apart from the ribosome, numerous protein factors participate in this process. Elongation factor 2 (eEF2) is one of these factors. eEF2 is an essential protein with a mol. LÄS MER

  3. 2. Adaptive Evolution of the Bacterial Translation Machinery

    Författare :Arindam De Tarafder; Suparna Sanyal; Michael Y. Pavlov; Ruben L. Jr. Gonzalez; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Translation; Translation machinery; Elongation; Evolution; RNA world; Cold bacteria; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : The process of protein synthesis via translation is of paramount importance for the existence of life on Earth. The bacterial translation machinery has embraced more than 3.5 billion years of molecular evolution to adapt and function efficiently under the provided physiological conditions. LÄS MER

  4. 3. Cryo-EM and Computational Biology of Macromolecular Complexes

    Författare :Andrew Emmerich; Suparna Sanyal; Erik Lindahl; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The ribosome is a large, ancient multicomponent macromolecular complex which is highly amenable to study by cryogenic electron microscopy (cryo-EM) and computation biology methods. This thesis delves into the structure of both prokaryotic and eukaryotic ribosomes in the context of determining a solution to emerging antimicrobial resistance. LÄS MER

  5. 4. A tale of two antibiotics : Fusidic acid and Viomycin

    Författare :Mikael Holm; Suparna Sanyal; Scott Blanchard; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Synthesis; Antibiotics; Fusidic acid; Viomycin; Translocation; Accuracy; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. LÄS MER

  7. 5. Studies on Translation Initiation and Termination in Escherichia coli

    Författare :Georgina Ibrahim Isak; Leif Isaksson; Suparna Sanyal; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; translation; ribosome; IF1; RF1; kasugamycin; tRNA; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Translation initiation factor 1 (IF1) has been shown to be an RNA chaperone. In order to find functional interactions that IF1 may have with rRNA, we have isolated second-site suppressors of a cold-sensitive IF1 mutant. LÄS MER