Sökning: "Fusidic Acid"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Fusidic Acid.
1. A tale of two antibiotics : Fusidic acid and Viomycin
Sammanfattning : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. LÄS MER
2. On Fusidic Acid Resistance in Staphylococcus Aureus
Sammanfattning : Controlling bacterial infections with antibiotics is central to modern health care. However, increasing bacterial resistance to antibiotics threatens effective therapy. This thesis concerns the use of the antibiotic fusidic acid, and novel analogues of fusidic acid, to treat topical infections caused by the bacterial pathogen Staphylococcu aureus. LÄS MER
3. Insights Into Protein Synthesis - Structural Aspects of Elongation Factor G and Fusidic Acid Inhibition
Sammanfattning : Elongation factor G (EF-G) catalyses the translocation step in protein synthesis on the ribosome. During this event the antibiotic Fusidic acid (FA) binds to and irreversably inhibits the release of the EF-G:GDP complex from the ribosome. LÄS MER
4. Studies on colonization and infection with Staphylococcus aureus and other microbes in skin disease
Sammanfattning : The skin is colonized with a wide range of microbes. Some offer vital protection from colonization and infection with pathogenic strains while others have the capacity to cause or exacerbate disease. LÄS MER
5. Characterizing Elongation of Protein Synthesis and Fusidic Acid Resistance in Bacteria
Sammanfattning : Protein synthesis is a highly complex process executed by the ribosome in coordination with mRNA, tRNAs and translational protein factors. Several antibiotics are known to inhibit bacterial protein synthesis by either targeting the ribosome or the proteins factors involved in translation. LÄS MER