Sökning: "post-transcriptional"

Visar resultat 21 - 25 av 117 avhandlingar innehållade ordet post-transcriptional.

  1. 21. Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing

    Författare :Zheng Ge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA elongation, is silent in most normal differentiated human cells due to the tight repression of its catalytic unit, telomerase reverse transcriptase (hTERT), whereas constitutive hTERT expression and telomerase activation are prerequisites for cellular immortalization/malignant transformation. As reconfiguration of chromatin acts like a master on/off switch, determining whether particular genes are active or inactive, the project was specifically designed to first elucidate molecular strategies that integrate diverse signalling pathways at the hTERT chromatin and consequently result in telomerase activation or repression in normal and malignant human cells. LÄS MER

  3. 22. Molecular and structural analysis of nucleoplasmic components connected to post-transcriptional steps of gene expression in the dipteran Chironomus tentans

    Författare :Nafiseh Sabri; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytologi;

    Sammanfattning : .... LÄS MER

  4. 23. Genomic feature identification in trypanosomatid parasites

    Författare :Daniel Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; genome sequence; bioinformatics; gene finding; Trypanosoma brucei; Leishmania major; strand asymmetry; trans splicing; polyadenylation; post-transcriptional control; uAUGs.;

    Sammanfattning : The trypanosomatid parasites cause death and suffering, among humans as well as livestock. Current drugs lack efficacy and cause severe side effects, and no vaccines are available. Increased knowledge of the biology of the parasites is vital for the development of new drugs. LÄS MER

  5. 24. Development and Applications of in vitro Models to Study Human Brain Evolution and Disease

    Författare :Daniela Grassi; Molekylär neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural reprogramming; Neural differentiation; Brain development; Huntington s disease; Induced Neuron; Neural Progenitor Cell; Brain evolution;

    Sammanfattning : Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. LÄS MER

  7. 25. Glucocorticosteroid effects on cytokine production: studies in a glucocorticosteroid resistance model and in allergic airway disease

    Författare :Susanne Larsson; allergologi och palliativ medicin Lungmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GM-CSF; cytokine; glucocorticoids; budesonide; IL-2; IL-4; IL-12; asthma; allergic rhinitis; allergic airway inflammation; Respiratory system; Andningsorganen;

    Sammanfattning : Glucocorticosteroids (GCS) are potent anti-inflammatory drugs, probably due to inhibitory effects on cytokine production. However, a small number of asthma patients seem GCS-resistant. Pro-inflammatory cytokines, such as interleukin-2(IL-2) and IL-4, produced during allergic airway inflammation have been proposed to induce the resistance to GCS. LÄS MER