Sökning: "post-transcriptional"

Visar resultat 16 - 20 av 117 avhandlingar innehållade ordet post-transcriptional.

1. 16. Ribosomal RNA Modification Enzymes : Structural and functional studies of two methyltransferases for 23S rRNA modification in Escherichia coli

   Författare :Avinash S. Punekar; Maria Selmer; Martino Bolognesi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome biogenesis; ribosome assembly; ribosomal RNA; peptidyltransferase center; domain V; post-transcriptional modification; methyltransferases; S-adenosyl-methionine; RlmM; Cm2498; RlmJ; m6A2030; X-ray crystallography; substrate recognition; substrate specificity; catalytic mechanism; evolution; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry;

   Sammanfattning : Escherichia coli ribosomal RNA (rRNA) is post-transcriptionally modified by site-specific enzymes. The role of most modifications is not known and little is known about how these enzymes recognize their target substrates. LÄS MER

3. 17. Organization and regulation of mitochondrial gene expression

   Författare :Roger Salvatori; Martin Ott; Benoit Kornmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial gene expression; post-transcriptional regulation; mitochondrial ribosome; protein-protein proximity; BioID; feedback loop; Biochemistry; biokemi;

   Sammanfattning : Mitochondria possess their own genome, remnant of the ancestral eubacterial endosymbiont DNA. This mitochondrial genome encodes mostly few key subunits of the respiratory chain. In order to synthesize these few proteins, mitochondria contain a complete gene expression machinery. LÄS MER

4. 18. The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression

   Författare :Cinzia Bersani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 is a p53 target gene and its RNA and protein levels increase after p53 protein activation. LÄS MER

5. 19. Post-transcriptional control of stem and cancer cell fate. New roles for an old RNA modification

   Författare :Nicola Guzzi; Avdelningen för molekylär hematologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; pseudouridine; translational control; Stem cells; tRNA-derived fragments; MDS;

   Sammanfattning : Recent advances in high-throughput sequencing technologies uncovered widespread RNA modifications on coding and non-coding RNAs collectively refer to as the epitranscriptome. However, we are only now starting to appreciate the impact of the epitranscriptome in regulating cell biology. LÄS MER

7. 20. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

   Författare :Azra Alajbegovic; Molekylär kärlfysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

   Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER