Sökning: "mRNA surveillance"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden mRNA surveillance.
1. Characterization of RNA exosome in Insect Cells : Role in mRNA Surveillance
Sammanfattning : The exosome, an evolutionarily conserved protein complex with exoribonucleolytic activity, is one of the key players in mRNA quality control. Little is known about the functions of the exosome in metazoans. We have studied the role of the exosome in nuclear mRNA surveillance using Chironomus tentans and Drosophila melanogaster as model systems. LÄS MER
2. Exploring mTOR-dependent regulation of mRNA translation in cancer
Sammanfattning : Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation step during mRNA translation. Subsets of transcripts are discriminated by structural and/or sequence features, and encode proteins involved in different biological functions. LÄS MER
3. Mechanisms for immune escape in epithelial ovarian cancer
Sammanfattning : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. LÄS MER
4. Vascular endothelial growth factor in renal cell carcinoma
Sammanfattning : Background. Angiogenesis is essential for tumour growth. Vascular endothelial growth factor (VEGF) and its isoforms were investigated in relation to the clinical course in a large number of patients with renal cell carcinoma (RCC). Methods. LÄS MER
5. Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes
Sammanfattning : Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. LÄS MER