Sökning: "cell nucleus"

Visar resultat 1 - 5 av 424 avhandlingar innehållade orden cell nucleus.

1. 1. Profilin : From the Cell Edge into the Nucleus

   Författare :Sara Sadi; Roger Karlsson; Maria Vartiainen; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; profilin; actin; microfilament system; nucleus; SRF; MRTF; MAL; transcription; microtubules; Cell Biology; cellbiologi;

   Sammanfattning : Internal and external signaling dependent changes in cell behavior are directly linked to force-generating remodeling of the actin microfilament system which is juxtaposed to the inside of the plasma membrane. This dynamic filament system is involved in many processes in the cytoplasm and the nucleus of eukaryotic cells. LÄS MER

3. 2. Functional organisation of the cell nucleus in the fission yeast, Schizosaccharomyces pombe

   Författare :Jenny Alfredsson Timmins; Pernilla Bjerling; Wendy Bickmore; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fission yeast; heterochromatin; subnuclear organisation; chromo domain proteins; boundary elements; transcriptional regulation; epigenetics; Molecular biology; Molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Genetics; Genetik; Molecular Biology; molekylärbiologi; Genetics; genetik;

   Sammanfattning : In eukaryotes the genome adopts a non-random spatial organisation, which is important for gene regulation. However, very little is known about the driving forces behind nuclear organisation. LÄS MER

4. 3. The release of histone proteins from cells via extracellular vesicles

   Författare :Uma Muthukrishnan; Jonathan Gilthorpe; Miles Trupp; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone; extracellular vesicles; exosomes; extracellular histones extracellular DNA; cellular stress; proteomics; ESCRT complex; Lrrn1; mid-hindbrain organizer; ovarian cancer; ascites;

   Sammanfattning : Histones are chromatin-associated proteins localized to the nucleus. However, extracellular histones are present in biofluids from healthy individuals and become elevated under disease conditions, such as neurodegeneration and cancer. LÄS MER

5. 4. The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival

   Författare :Maria Ekman; Marene Landström; Carl-Henrik Heldin; Jonas Fuxe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta; cell migration; invasion; apoptosis; Smad7; APC; ATM; TRAF6; p53; PC3U; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. LÄS MER

7. 5. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer

   Författare :Jonas Ungerbäck; Peter Söderkvist; Ola Hermanson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Notch signalling; T-cell lymphoma; colorectal cancer; Wnt signalling; transcription; Medical cell biology; Medicinsk cellbiologi;

   Sammanfattning : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. LÄS MER