Sökning: "lymphomagenesis"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet lymphomagenesis.

1. 1. Myc-induced Lymphomagenesis : In vivo assessment of downstream pathways

   Författare :Sara Rimpi; Jonas Nilsson; Juha Klefström; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; lymphomagenesis; Aurora kinases; polyamine; glycolysis; targeting; mouse models of cancer; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Myc oncogenes encode transcription factors that bind to E-box sequences in DNA, driving the expression of a large number of target genes and are deregulated in approximately 70% of human cancers. Deregulated Myc expression cause enhanced proliferation (which is counteracted by apoptosis), angiogenesis and cancer. LÄS MER

3. 2. Establishment and characterization of a murine T-cell lymphoma/leukemia model

   Författare :Ann-Sofie Johansson; Dan Holmberg; Magnus Lindskog; Finn Skou Pedersen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse model; T-cell lymphoma; Moloney murine leukemia virus; proviral integration; lymphomagenesis; COX-2; omega 3; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : Mouse models of human disease are valuable tools for studying pathogenesis and for evaluating novel therapies. T-cell lymphoma is a relatively rare disease in humans, affecting 100-150 persons yearly in Sweden. It exists in both aggressive and more indolent forms. LÄS MER

4. 3. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

   Författare :Linus Plym Forshell; Jonas Nilsson; Lars-Gunnar Larsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Myc; Decitabine; Pim kinase; RCAS-tva; Neurobiology; Neurobiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. LÄS MER

5. 4. Oncogenic mechanisms of AIDS-related neoplasia in humans and SIV infected monkeys

   Författare :Esmeralda Castaños-Vélez; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :immunosuppression; AIDS; lymphoma; Kaposi s sarcoma; EBV HVMF-1; HHV8; cell proliferation; apoptosis; animal model;

   Sammanfattning : Patients with AIDS or immunosuppressive post-transplant therapy are at high risk to develop Kaposi's sarcoma (KS) and malignant lymphoma that represent clinically lethal complications. Lymphomagenesis in simian immunodeficiency virus (SIV) infected cynomolgus monkeys has been shown to be highly similar to lymphomagenesis in immunosuppressed patients. LÄS MER

7. 5. Characterization of the genome and tumor microenvironment of human B-cell lymphoma

   Författare :Xiaofei Ye; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Non-Hodgkin lymphoma (NHL) is the 13th most common type of cancer worldwide in 2020 and consists mainly of human B-cell lymphoma (approximately 85%). Diffuse large B-cell lymphoma (DLBCL) is the most common NHL subtype (approximately 30%). LÄS MER