Sökning: "targeting"

Visar resultat 1 - 5 av 1092 avhandlingar innehållade ordet targeting.

  1. 1. Two-Step Targeting for Effective Radionuclide Therapy Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Amelie Fondell; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. LÄS MER

  2. 2. Tumour Targeting Using Radiolabelled EGF Conjugates Preclinical Studies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Åsa Liljegren Sundberg; Uppsala universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; MEDICINE Physiology and pharmacology Radiological research Radiation biology; MEDICIN Fysiologi och farmakologi Radiologisk forskning Strålningsbiologi;

    Sammanfattning : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. LÄS MER

  3. 3. Tumor Cell Targeting of Stabilized Liposome Conjugates Experimental studies using boronated DNA-binding agents

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Erika Bohl Kullberg; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; Liposome; EGF; HER-2; Targeting; boron; Biomedicin; MEDICINE Microbiology; immunology; infectious diseases Microbiology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Mikrobiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Sammanfattning : To further develop cancer therapy, targeted delivery of cell killing agents directly to tumor cells is an interesting approach. This thesis describes the development of PEG-stabilized liposome conjugates targeting either epidermal growth factor receptor (EGFR) using its natural ligand EGF, or human epidermal growth factor receptor 2 (HER-2) using the antibody trastuzumab. LÄS MER

  4. 4. Targeting the Unarmed Strategic Rebel Violence in Civil War

    Detta är en avhandling från Uppsala : Institutionen för freds- och konfliktforskning

    Författare :Lisa Hultman; Uppsala universitet.; [2008]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; one-sided violence; violence against civilians; killing; civil war; rebel group; rebel strategy; bargaining; count model; Renamo; Mozambique; SOCIAL SCIENCES Social sciences Political science Peace and conflict research; SAMHÄLLSVETENSKAP Socialvetenskap Statsvetenskap Freds- och konfliktforskning;

    Sammanfattning : Rebel attacks on civilians constitute one of the gravest threats to human security in contemporary armed conflicts. But why do rebel groups kill civilians? The dissertation approaches this question from a strategic perspective, trying to understand when and why rebel groups are likely to target civilians as a conflict strategy. LÄS MER

  5. 5. Targeting Infectious Disease Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna M. Jansson; Uppsala universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. LÄS MER