Sökning: "homology modelling"

Visar resultat 11 - 15 av 27 avhandlingar innehållade orden homology modelling.

  1. 11. Molecular mechanisms of HLA associations with myasthenia gravis

    Författare :Peter Hjelmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myasthenia gravis; MHC; HLA; T cell receptor; acetylcholine receptor; TNF-a; thymus complex disease trait; autoimmunity; molecular modelling; stratification; DNA polymorphisms;

    Sammanfattning : Myasthenia gravis (MG) is a neuromuscular disease characterised by muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR). MG has a complex pattern of inheritance and several genetic and environmental factors are important in conferring susceptibility to the disease. LÄS MER

  3. 12. New methods for protein structure threading and domain identification

    Författare :Mats Lindstam; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomatematik; Molecular biophysics; Molekylär biofysik; medicinsk informatik; Bioinformatik; biomathematics biometrics; medical informatics; structure prediction; Bioinformatics; domain identification; Structural bioinformatics; threading;

    Sammanfattning : The availability of three-dimensional structures of proteins has provided enormous insight into the detailed molecular machinery of the living cell. Since the late 1950s and early 1960s, experimental methods for deriving protein structures have contributed more than 30,000 entries to the Protein Data Bank, representing the collected knowledge of protein and other macromolecular structures. LÄS MER

  4. 13. Evolutionary Approaches to Sequence Alignment

    Författare :Marcin Bogusz; Simon Whelan; Jeffrey Thorne; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular evolution; multiple sequence alignment; pair hidden Markov models; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Molecular evolutionary biology allows us to look into the past by analyzing sequences of amino acids or nucleotides. These analyses can be very complex, often involving advanced statistical models of sequence evolution to construct phylogenetic trees, study the patterns of natural selection and perform a number of other evolutionary studies. LÄS MER

  5. 14. Exploring Ligand Binding in HIV-1 Protease and K+ Channels Using Computational Methods

    Författare :Fredrik Österberg; Johan Åqvist; Olle Edholm; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; hERG; KcsA; AutoDock; LIE; molecular dynamics; ion channels; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Understanding protein-ligand interactions is highly important in drug development. In the present work the objective is to comprehend the link between structure and function using molecular modelling. LÄS MER

  7. 15. C4b-binding protein: Identification of binding sites and a possible function of the interaction with protein S

    Författare :Joanna Webb; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; apoptosis; binding sites; complement; C4b-binding protein; protein S; Klinisk kemi;

    Sammanfattning : The subject of this thesis is plasma protein C4b-binding protein (C4BP). C4BP is an important regulator of the classical pathway of the complement system, a cascade-like system comprised of over 35 proteins, which partakes in the defence against micro-organisms and is involved of clearance of immune-complexes and apoptotic cells. LÄS MER