Sökning: "heart muscle"
Visar resultat 1 - 5 av 181 avhandlingar innehållade orden heart muscle.
1. Heart Regeneration : Lessons from the Red Spotted Newt
Sammanfattning : Unlike mammals, adult salamanders possess an intrinsic ability to regenerate complex organs and tissue types, making them an exciting and useful model to study tissue regeneration. The aims of this thesis are two fold, (1) to develop and characterize a reproducible cardiac regeneration model system in the newt, and (2) to decipher the cellular and molecular underpinnings involved in regeneration. LÄS MER
2. Structure and function of the cytoskeleton in cardiac and skeletal muscle
Sammanfattning : We have examined the functional and structural roles of the cytoskeletal protein desmin in cardiac and skeletal muscles using a genetically modified mouse (Des-/-) with the desmin gene ablated. Desmin forms filaments at the Z-disks in the striated muscle sarcomere, have connections to the sarcolemma and most likely align sarcomeres and whole cells. LÄS MER
3. The muscle cytoskeleton of mice and men : Structural remodelling in desmin myopathies
Sammanfattning : The muscle fibre cytoskeleton of skeletal and heart muscle cells is composed mainly of intermediate filaments (IFs), that surround the myofibrils and connect the peripheral myofibrils with the sarcolemma and the nuclear membrane. Desmin is the first muscle specific IF protein to be produced in developing muscles and is the main IF protein in mature muscles. LÄS MER
4. Being physically active as an adult with congenital heart disease
Sammanfattning : Background: Due to advances in medical and surgical care adults with congenital heart disease (CHD) is a growing and aging population, that now outnumbers the children with CHD. In general, adults with CHD have reduced aerobic exercise capacity and nearly half of the patients do not reach current recommendations on physical activity. LÄS MER
5. Physical Activity and Cardiovascular Disease
Sammanfattning : The aim was to investigate associations of fitness and types and levels of physical activity with subsequent risk of cardiovascular disease.Four large-scale longitudinal cohort studies were used. The exposures were different measures related to physical activity and the outcomes were obtained through linkage to the Swedish In-Patient Register. LÄS MER