Sökning: "cyclin D"

Visar resultat 6 - 10 av 24 avhandlingar innehållade orden cyclin D.

  1. 6. PREDICTIVE AND PROGNOSTIC MARKERS IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

    Författare :Eva Henriksson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CCND1; cyclin D1; head and neck cancer; cisplatin; TP53; cell proliferation parameters; squamous cell carcinoma; predictive marker;

    Sammanfattning : Survival of patients with locally advanced head and neck squamous cell cancer(HNSCC)is poor, with an overall survival < 50%, despite diagnostic and therapeutic advances. The identification of prognostic and predictive markers could help optimizing treatment. LÄS MER

  3. 7. The prognostic significance of uPA, uPAR an d the cytokine IL-1-alpha in urinary bladder cancer

    Författare :Maria Seddighzadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Urinary bladder cancer; urokinase; urokinase receptor; interleukin-1;

    Sammanfattning : Tumor invasion and metastasis are the major causes of cancer-related death. Proteases are important for the invasive and metastatic propensities of tumors. We have studied the mechanism underlying endogenous expression of the serine protease urokinase plasminogen activator (uPA) by human breast cancer cells. LÄS MER

  4. 8. Single cell analysis of checkpoints in G1

    Författare :Hanna-Stina Martinsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell cycle; restriction point; cyclin D; pRb; rRNA synthesis; cell growth; attachment;

    Sammanfattning : It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular growth factors, is often aberrant in cancer cells. LÄS MER

  5. 9. Cell cycle control in G1 : restriction points for growth factors and anchorage dependence

    Författare :Peter Zickert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cell cycle; cyclin E; growth control; growth factor; restriction point; ECM; anchorage;

    Sammanfattning : Background: The eukaryotic cell cycle consists of four well-defined phases. During the S phase DNA is replicated and during the M phase the chromosomes are segregated to daughter cells. The time gap between completion of M phase and entry into S phase is called G1. The time gap between S phase and mitosis is called G2. LÄS MER

  7. 10. Synovial sarcoma : molecular, biological and clinical implications

    Författare :Maria Törnkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :synovial sarcoma; translocations; fusion genes; SS18-SSX; IGF-1R; cyclin D1; antisense oligodeoxynucleotides.;

    Sammanfattning : Synovial sarcoma is a rare but mostly aggressive soft tissue tumor that mainly affects children and young adults. The tumor usually occurs in the vicinity of large joints, and may be subdivided into a classical biphasic type, a monophasic type or a poorly differentiated type, depending on histomorphological appearance. LÄS MER