Sökning: "cyclin D"

Visar resultat 16 - 20 av 24 avhandlingar innehållade orden cyclin D.

  1. 16. Wnt/β-Catenin Signalling in Parathyroid Tumours

    Författare :Peyman Björklund; Gunnar Westin; Göran Åkerström; Tommy Andersson; Uppsala universitet; []
    Nyckelord :Surgery; Hyperparathyroidism; β-catenin; Mutation; Human parathyroid cell line; LRP5; Alternative splicing; Kirurgi;

    Sammanfattning : Primary hyperparathyroidism (pHPT) due to parathyroid tumours with hypersecretion of parathyroid hormone and hypercalcaemia is a common disease with incompletely understood etiology affecting more than 1 % of the population, primarily postmenopausal women. In secondary hyperparathyroidism (sHPT), parathyroid tumours develop in response to calcium and vitamin D deficiency generally in patients with uraemia. LÄS MER

  3. 17. Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

    Författare :Sophie Lehn; Malmö Molekylär patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; subgroups; proliferation; migration; stem cells; tamoxifen; estrogen receptor;

    Sammanfattning : Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. LÄS MER

  4. 18. Thymidylate synthase expression in colorectal cancer : its role as a prognostic factor and a predictive factor in adjuvant 5-fluorouracil-based chemotherapy

    Författare :David Edler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Colorectal cancer; thymidylate synthase; immunohistochemistry; prognostic factor; 5-fluorouracil; adjuvant treatment;

    Sammanfattning : The enzyme thymidylate synthase (TS) plays a central role in DNA synthesis and is therefore an important target for chemotherapeutic treatment. We have studied the prognostic value of immunohistochemically detected TS on slices of formalin-fixed. paraffin embedded stored colorectal tumors using the monoclonal antibody TS 106. LÄS MER

  5. 19. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

    Författare :Melker Göransson; Göteborgs universitet; []
    Nyckelord :Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

    Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER

  7. 20. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers

    Författare :Johanna Smeds; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CDKN2A; ARF; p53; cell cycle regulation; mutation; melanoma; esophageal squamous cell carcinoma;

    Sammanfattning : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. LÄS MER