Sökning: "cyclin D"

Visar resultat 21 - 24 av 24 avhandlingar innehållade orden cyclin D.

  1. 21. The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis

    Författare :Minna Thullberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor protein p16INK4a and its family members p15INK4b, p18INK4c and p19INK4d (the INK4 proteins) inhibit the cyclin-dependent kinases CDK4 and CDK6, which are key regulators of the retinoblastoma protein (pRb). pRb guars entry into the S phase of the mammalian cell division cycle (the cell cycle), a process evolved to ensure balanced cell proliferation. LÄS MER

  3. 22. Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons

    Författare :Åsa Wallén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred to as orphan receptors. LÄS MER

  4. 23. Improved human papillomavirus DNA typing methods and biology of cervival cancer

    Författare :Biying Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical cancer; human papillomavirus; Pyrosequencing; chemokine receptors; adenoassociated virus; biomarkers; and cell cycle checkpoint.;

    Sammanfattning : Cervical cancer is the second most common cancer among women worldwide. Persistent HPV has been identified as a main risk factor in cervical cancer development. Oncoproteins E6 and E7 of highrisk HPV interact with cellular proteins, subverting cell cycle checkpoint, inducing carcinogenesis. LÄS MER

  5. 24. Development of intimal hyperplasia in transplant arteriosclerosis

    Författare :Piotr Religa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Vascular disease is the main cause of disability and mortality in the western world and the major limiting factor for long- term survival of transplanted organs. Occlusive vascular lesions lead to ischemia and structural changes in organs and in transplant arteriosclerosis and restenosis after endovascular procedures, narrowing of the vessel lumen is partly due to intimal hyperplasia caused by smooth muscle cells (SMCs). LÄS MER