Sökning: "cellular aging"

Visar resultat 1 - 5 av 67 avhandlingar innehållade orden cellular aging.

1. 1. Damage Segregation and Cellular Rejuvenation in Saccharomyces cerevisiae

   Författare :Sandra Malmgren Hill; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; protein damage; quality control; metacaspase; aggregates; segregation; vacuole;

   Sammanfattning : The process of aging is defined as a time-dependent decline in cellular functionality, and aging is thought to have evolved as organisms were optimized for reproduction, at the cost of an imperfect repair and maintenance system. As a consequence, different kinds of dysfunctional components and damage accumulate over time. LÄS MER

3. 2. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

   Författare :Veronica Andersson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; aging; aggregates; proteostasis; proteasome; disaggregation; peroxiredoxins; asymmetric inheritance; S. cerevisiae;

   Sammanfattning : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. LÄS MER

4. 3. Mitochondrial translation and its impact on protein homeostasis and aging

   Författare :Tamara Suhm; Martin Ott; Aleksandra Trifunovic; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondrial ribosome; mitochondrial translation accuracy; mitochondrial communication; interorganellar communication; stress signaling; proteostasis; aging; yeast genetics; mitochondrial protein quality control; mitochondrial membrane protein insertion; Biochemistry; biokemi;

   Sammanfattning : Besides their famous role as powerhouse of the cell, mitochondria are also involved in many signaling processes and metabolism. Therefore, it is unsurprising that mitochondria are no isolated organelles but are in constant crosstalk with other parts of the cell. LÄS MER

5. 4. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin

   Författare :Sarah Hanzén; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; Caloric restriction; Oxidative stress; Peroxiredoxins; Proteostasis; Protein aggregates; Ubiquitin-proteasome system;

   Sammanfattning : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. LÄS MER

7. 5. On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control

   Författare :David Öling; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Protein damage; Segregation; Transcriptional silencing; rDNA; UBP3; SIR2; Protein aggregates;

   Sammanfattning : Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. LÄS MER