Sökning: "cell carcinoma"
Visar resultat 16 - 20 av 563 avhandlingar innehållade orden cell carcinoma.
16. Studies on Tissue Factor with Focus on Cell Signaling and Cancer
Sammanfattning : This thesis have explored the functions of the protein Tissue Factor (TF), which together with its ligand coagulation factor VII/VIIa (FVII/FVIIa) forms a proteolytic complex that functions in initiation of blood coagulation and activation of cell signaling.In paper I, the mechanisms behind the observation that TF/FVIIa signaling protects cells from apoptosis were further investigated. LÄS MER
17. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis
Sammanfattning : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. LÄS MER
18. TGFβ and LXR signaling in hepatocellular carcinoma
Sammanfattning : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). LÄS MER
19. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck
Sammanfattning : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. LÄS MER
20. p63 and potential p63 targets in squamous cell carcinoma of the head and neck
Sammanfattning : Squamous cell carcinoma of the head and neck (SCCHN), the 6th most common cancer worldwide, has a low 5-year survival. Disease as well as treatment often causes patients severe functional and aesthetic problems. LÄS MER