Sökning: "SCCHN"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet SCCHN.

  1. 1. p63 and potential p63 targets in squamous cell carcinoma of the head and neck

    Författare :Linda Boldrup; Karin Nylander; Wendy Weinberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SCCHN; p63; Cox-2; EGFR; β-catenin; PP2A; p53; Tumour biology; Tumörbiologi;

    Sammanfattning : Squamous cell carcinoma of the head and neck (SCCHN), the 6th most common cancer worldwide, has a low 5-year survival. Disease as well as treatment often causes patients severe functional and aesthetic problems. LÄS MER

  3. 2. p63 and epithelial homeostasis : studies of p63 under normal, hyper-proliferative and malignant conditions

    Författare :Xiaolian Gu; Karin Nylander; Antonio Costanzo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; psoriasis; SCCHN; epithelium; homeostasis; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : Background: The p63 gene is a member of the p53 transcription factor family and can produce six different proteins using two promoters and differential splicing. Expression of p63 is required for proper formation of epithelial tissues. LÄS MER

  4. 3. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

    Författare :Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

    Sammanfattning : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. LÄS MER

  5. 4. Clinical investigation and application of Artificial Intelligence in diagnosis and prognosis of squamous cell carcinoma of the head and neck

    Författare :Amir M. Salehi; Karin Nylander; Lena Norberg-Spaak; Wojciech Golusinski; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SCCHN; SCCOT; Recurrence; ML; PET CT; mRNA; transcriptomic; proteomic; Diabetes; AI; Oto-Rhino-Laryngology; oto-rhino-laryngologi;

    Sammanfattning : Background: In Sweden around 1400 people are affected by head and neck cancer each year, and around 400 of these tumours are located in the mobile tongue (SCCOT). A major problem with these tumours is the high degree of relapse. LÄS MER

  7. 5. Wilms' tumor gene 1 in different types of cancer

    Författare :Xingru Li; Aihong Li; Karin Nylander; Eva Lundin; Xiaolian Gu; David M. Loeb; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WT1; AML; MRD; ccRCC; SNPs; DNA methylation; SCCHN; p63; Clinical Chemistry; klinisk kemi;

    Sammanfattning : The Wilms’ tumor gene 1 (WT1) was first reported as a tumor suppressor gene in Wilms’ tumor. However, later studies have shown the oncogenic properties of WT1 in a variety of tumors. It was recently proposed that WT1 was a chameleon gene, due to its dual functions in tumorigenesis. LÄS MER