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Visar resultat 6 - 10 av 113 avhandlingar som matchar ovanstående sökkriterier.

1. 6. Death mechanisms compromising hippocampal neurogenesis after status epilepticus

   Författare :Christine Ekdahl Clementson; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; minocycline; lipopolysaccharide; microglia activation; status epilepticus; epilepsy; cysteinyl aspartate-specific proteases; apoptosis; neurogenesis; progenitor cell progeny;

   Sammanfattning : Status epilepticus (SE) leads to neurodegeneration as well as neurogenesis in the adult rat hippocampus. This thesis demonstrates that even if the neurogenic response initially is very pronounced, with a several-fold increase in cell proliferation, the survival of the newly formed neurons is compromised by a death mechanism involving mitochondria-related caspases. LÄS MER

3. 7. Skeletal muscle potassium and magnesium in diuretic treated patients : effects of potassium - sparing diuretics of magnesium supplementation

   Författare :Lars Widman; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long-term diuretic treatment; arterial hypertension; congestive heart failure; muscle biopsy; intracellular electrolytes Mg; K ; spironolactone; triamterene; amiloride; peroral magnesium aspartate - hydrochloride;

   Sammanfattning : .... LÄS MER

4. 8. Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease

   Författare :Christina Unger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Abeta; Alzheimer s disease; APP; nAChR; NMDA receptors; synaptophysin; transgenic mice; treatment;

   Sammanfattning : The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial questions are if Abeta has a neuronal function in the brain and how it interacts with the neurotransmitter system in AD. LÄS MER

5. 9. CNS Targets for GH and IGF-1 : Emphasis on Their Regulation in Relation to Cognitive Processes

   Författare :Madeleine Le Grevès; Fred Nyberg; Anders Hallberg; Sigbritt Werner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Central nervous system; Growth hormone; Insulin-like growth factor-1; Receptor mRNA regulation; N-methyl-D-aspartate receptor mRNA; Morris water maze; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

   Sammanfattning : The interest for the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and its role in the central nervous system (CNS) has grown during the past decade. GH has been associated with psychological functions as sleep, mood, general well-being and learning and memory. LÄS MER

7. 10. Acute toluene effects on neurotransmission in the central nervous system

   Författare :Karl Stengård; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :acetylcholine; aspartate; cerebellum; dopamine; GABA; globus pallidus; glutamate; microdialysis; rat; striatum; toluene; ;

   Sammanfattning : The aim of this thesis was to develop a method to study the effects of toluene in the central nervous system of the rat. Microdialysis on awake rats was used to study toluene's effects on the transmission of dopamine, acetylcholine, glutamate and aspartate in the striatum, and on GABA in the striatum, the cerebellum and the globus pallidus. LÄS MER