Sökning: "alkaline sphingomyelinase"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden alkaline sphingomyelinase.

  1. 1. Alkaline Sphingomyelinase; A Potential Inhibitor in Colorectal Carcinogenesis

    Författare :Erik Hertervig; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Cytologi; cancerology; oncology; Cytology; Gastroenterologi; Gastro-enterology; HT-29; MIN mouse; FAP; colorectal cancer; human; alkaline sphingomyelinase;

    Sammanfattning : Sphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. LÄS MER

  3. 2. Digestion and Absorption of Sphingomyelin from Milk

    Författare :Lena Nyberg; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; intestine; sphingolipid; ceramidase; sphingomyelinase; ceramide; Gastroenterologi;

    Sammanfattning : Sphingomyelin (SM) is a major component of mammalian cell membranes. Due to its widespread occurrence it is a dietary component, occurring mainly in milk, eggs, meat and fish. In the cell membrane SM was earlier considered to be only a structural element, which interacts with cholesterol and forms a system for bilayer stabilization. LÄS MER

  4. 3. Intestinal immune cells in health and disease. Dissecting histological characteristics of inflammatory bowel disease and inflamed lung using quantitative immunohistochemical image analysis

    Författare :Manar Alyamani; Adaptivt immunförsvar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IBD; CD; UC; Quantitative imaging; COVID -19; NPP7 Nucleotide phosphodiesterase pyrophosphatase 7; alkaline sphingomyelinase; histopathology; Multiplexed IHC; Immunohistochemical staining; S1P Sphingosine-1-phosphate;

    Sammanfattning : .... LÄS MER

  5. 4. Experimental Studies of Ursolic Acid and Alkaline Sphingomyelinase in Colon Cancer and Colitis

    Författare :David Andersson; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Sphingomyelin (SM) is a sphingolipid present in all eukaryotic cell membranes. Hydrolysis of SM by sphingomyelinase (SMase) generates ceramide, which has effects on cell-cycle regulation and apoptosis. LÄS MER

  7. 5. Studies on familial adenomatous polyposis

    Författare :Jan Björk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Familial adenomatous polyposis (FAP) is a hereditary disorder caused by mutations in the adenomatous polyposis coli (APC) gene, which leads to adenoma formation and subsequently to cancer, predominantly in the colon and the rectum but also in the duodenum. The cancer morbidity and mortality can be decreased by presymtomatic screening and surgical treatment. LÄS MER