Sökning: "MIN mouse"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden MIN mouse.

  1. 1. Studies on leukotriene B4 and alarmins in inflammatory responses

    Författare :Min Wan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial polypeptides, which belong to the alarmin family known to promote innate and adaptive immune reactions in response to tissue infection or injury. LÄS MER

  3. 2. On ischemia/reperfusion injury and rejection in concordant xenotransplantation to the rat

    Författare :Daniel Jan Lukes; Göteborgs universitet; []
    Nyckelord :Concordant; xenotransplantation; rat; hamster; mouse; rejection; necrosis; PCr; ß-ATP; ROS; SOE light; I RP; IPC;

    Sammanfattning : Studies in concordant (without preformed antibodies) rodent xenotransplantation (transplantation between species) models have focused, to date, on immunological disparities. In allotransplantation (transplantation within species), there is evidence suggesting that early ischemic events may contribute to later rejection episodes and to the development of chronicrejection features. LÄS MER

  4. 3. Alkaline Sphingomyelinase; A Potential Inhibitor in Colorectal Carcinogenesis

    Författare :Erik Hertervig; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Cytologi; cancerology; oncology; Cytology; Gastroenterologi; Gastro-enterology; HT-29; MIN mouse; FAP; colorectal cancer; human; alkaline sphingomyelinase;

    Sammanfattning : Sphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. LÄS MER

  5. 4. Applications of organ culture of the mouse inner ear

    Författare :Diana Berggren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ culture; embryonic inner ear; intercellular junctions; aminoglycosides; statoacoustic ganglion; intermediate filaments; collagen; endolymph;

    Sammanfattning : The embryonic mouse inner ear was used as a model with which to study ototoxicity and tissue interactions. The inner ear anlage can be explanted and cultured in vitro from about the 12th gestational day (gd), and will differentiate parallel with the inner ear developing in vivo until a time corresponding to birth (21st gd). LÄS MER

  7. 5. On the Role of Polyamines in Apoptosis

    Författare :Cecilia Hegardt; Bröstcancer-genetik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SSAT; DENSPM; spermine; polyamines; mitochondrial membrane potential; cytochrome c; caspase; flow cytometry; Jurkat cells; mouse thymocytes; thymus in vivo; programmed cell death; Dexamethasone-induced apoptosis; Fas-induced apoptosis; AdoMetDC; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; Clinical biology; Klinisk biologi; Animal physiology; Djurfysiologi;

    Sammanfattning : Apoptosis is a kind of death that is best described as cellular suicide and it is important for normal tissue homeostasis. The process can be induced by a number of different stimuli and the dying cell goes through a defined pathway terminating in typical biochemical and morphological alterations of the cell. LÄS MER