Sökning: "TaqMan"

Visar resultat 21 - 25 av 39 avhandlingar innehållade ordet TaqMan.

  1. 21. Genetic studies of neuroblastoma with emphasis on the apoptotic pathway

    Författare :Frida Abel; Göteborgs universitet; []
    Nyckelord :child; cancer; neuroectodermal; neural crest; loss of heterozygosity; LOH; bcl-2; mcl-1; apaf-1; caspase-2; caspase-3; caspase-9; PIN; DLC-1; caspase-2;

    Sammanfattning : Aim: The objective of this thesis was to find genes and chromosomal regions involved in neuroblastoma (NB) tumor progression. NB is a childhood tumor of the sympathetic nervous system that generally occurs spontaneously. LÄS MER

  3. 22. Endocrine and paracrine factors related to pregnancy and infertility

    Författare :Frida Hosseini Akram; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Unexplained infertility, one of the common gynecological disorders, affecting 10 to 15 % of women worldwide. Recurrent pregnancy loss affects approximately 1 to 3 % of pregnant women with an unknown etiology in 50 % of cases. Endocrine dysfunctions, including thyroid dysfunction, are one of the related factors to female reproductive disturbances. LÄS MER

  4. 23. Genetic association studies in stroke

    Författare :Claes Ladenvall; Göteborgs universitet; []
    Nyckelord :stroke; ischemic stroke subtypes; subarachnoid hemorrhage; genetics; polymorphism; fibrinolysis; tPA; PAI-1; TAFI; CRP; Factor XIII;

    Sammanfattning : Stroke is the third most common cause of death and the most common cause of disability in adults in developed countries. It is a complex disease in which genetic and environmental factors make about equal contributions. LÄS MER

  5. 24. PPAR delta : its role in cholesterol metabolism

    Författare :Josefin Skogsberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Peroxisome proliferator activated receptor delta; polymorphism; association studies; LDL-cholesterol; coronary heart disease; LDL receptor; gene expression;

    Sammanfattning : Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors that regulate several biological processes, many of which are crucial for energy homeostasis. Three different isotypes have been identified; PPARalpha, PPARdelta and PPARgamma that are encoded by different genes and show different expression patterns and functions. LÄS MER

  7. 25. On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease

    Författare :Anna Tjärnlund-Wolf; Göteborgs universitet; []
    Nyckelord :tissue-type plasminogen activator; plasminogen activator inhibitor type-1; polymorphism; endothelium; Sp1; gene expression; myocardial infarction; ischemic stroke;

    Sammanfattning : Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus (-7,351C>T), located within a GC-box in the retinoic acid (RA) and steroid hormone responsive t-PA enhancer. LÄS MER