Sökning: "Mikael Holm"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Mikael Holm.

  1. 1. A tale of two antibiotics : Fusidic acid and Viomycin

    Författare :Mikael Holm; Suparna Sanyal; Scott Blanchard; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Synthesis; Antibiotics; Fusidic acid; Viomycin; Translocation; Accuracy; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. LÄS MER

  3. 2. Aquaporins in Infection and Inflammation

    Författare :Angelika Holm; Elena Vikström; Karl-Eric Magnusson; Vesa Loitto; Jonas Wetterö; Mikael Rhen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The ability of eukaryotic cells to change their shape and to migrate directionally is highly dependent on active volume regulation in cells building up tissues as well as in individual cells. Transmembrane fluxes of water via specialized water channels, called aquaporins (AQPs), facilitate the changes of volume and shape, which additionally require a complex interplay between the plasma membrane and the cytoskeleton. LÄS MER

  4. 3. The Chorda Tympani Nerve : Role in Taste Impairment in Middle Ear Disease and after Ear Surgery

    Författare :Katarina Berling Holm; Magnus von Unge; Mikael Karlberg; Uppsala universitet; []
    Nyckelord :Chorda tympani nerve; ear surgery; taste; chronic suppurative otitis media; otosclerosis; electrogustometry; filter paper disc method; quality of life; transmission electron microscopy; degeneration; sprouting; Surgery; Kirurgi;

    Sammanfattning : The chorda tympani nerve, also known as the taste nerve, runs uncovered through the middle ear cavity, a localization that exposes the nerve to pathological processes and surgical trauma in the middle ear. People operated on for otosclerosis tend to complain more about postoperative taste disturbances than those operated on for chronic otitis media. LÄS MER

  5. 4. The complex internationalization process unfolded : The case of Atlas Copco’s entry into the Chinese mid-market

    Författare :Mikael Eriksson; Ulf Holm; Mats Forsgren; Rian Drogendijk; Niina Nummela; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; International Business; Internationalization process; Complexity; Process theory; Strategy process; Evolutionary process; Political process; Business Studies; Företagsekonomi;

    Sammanfattning : Despite its contemporary relevance, we still have limited empirical knowledge about the forces underlying complex internationalization processes as when multinational corporations (MNCs) seek to enter new growing markets. Based on a real-time process study comprising ninety interviews and two hundred hours of observation made between 2009 and 2012, Atlas Copco’s entry into the Chinese mid-market was investigated. LÄS MER

  7. 5. Platelets and airway remodeling : Mechanisms involved in platelet-induced fibroblast and airway smooth muscle cell proliferation in vitro

    Författare :Ann-Charlotte B. Svensson Holm; Torbjörn Bengtsson; Eva Lindström; Mikael Adner; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Airway remodeling is a contributing cause to the pathological structural changes, such as increased cell proliferation, observed in asthma. Platelets have been found in autopsy lungmaterial obtained from asthmatic patients and are well known to induce proliferation in vitro of a variety of cells. LÄS MER