Sökning: "SHP-2"
Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet SHP-2.
1. Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1
Sammanfattning : x.... LÄS MER
2. CD47–SIRPα : an interaction of importance for bone cell differentiation
Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER
3. Expression and function of the protein tyrosine phosphatases SHP-1 and SHP-2 in prostate cancer
Sammanfattning : Prostate cancer is one of the most frequent cancers in males in Western countries. Radical prostatectomy serves as the first line of treatment for patients with localised prostate cancer. However, in many cases the cancer will recur. It is currently difficult to identify those patients at a high risk of tumour recurrence. LÄS MER
4. Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
Sammanfattning : Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, including cancers and cardiovascular disease, and is thus a known driver of disease progression. LÄS MER
5. Specific signaling through heteromeric PDGF receptor complexes
Sammanfattning : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. LÄS MER