Sökning: "Protein Structure"

Visar resultat 1 - 5 av 526 avhandlingar innehållade orden Protein Structure.

1. 1. Protein structure prediction : Zinc-binding sites, one-dimensional structure and remote homology

   Detta är en avhandling från Stockholm : Department of Materials and Environmental Chemistry (MMK), Stockholm University

   Författare :Nanjiang Shu; Stockholms universitet.; [2010]
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; zinc-binding; profile; homology detection; shape string; Structural Chemistry; strukturkemi;

   Sammanfattning : Predicting the three-dimensional (3D) structure of proteins is a central problem in biology. These computationally predicted 3D protein structures have been successfully applied in many fields of biomedicine, e.g. family assignments and drug discovery. LÄS MER

3. 2. Molecular principles of protein stability and protein-protein interactions

   Detta är en avhandling från Stockholm : Department of Materials and Environmental Chemistry (MMK), Stockholm University

   Författare :Christofer Lendel; KTH.; [2005]
   Nyckelord :TEKNIKVETENSKAP; TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.;

   Sammanfattning : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. LÄS MER

4. 3. Protein Structure Prediction : Model Building and Quality Assessment

   Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

   Författare :Björn Wallner; Stockholms universitet.; [2005]
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; proteinstrukturförutsägelse;

   Sammanfattning : Proteins play a crucial roll in all biological processes. The wide range of protein functions is made possible through the many different conformations that the protein chain can adopt. The structure of a protein is extremely important for its function, but to determine the structure of protein experimentally is both difficult and time consuming. LÄS MER

5. 4. Structure determination and thermodynamic stabilization of an engineered protein-protein complex

   Detta är en avhandling från Stockholm: KTH, Bioteknologi

   Författare :Elisabet Wahlberg; KTH.; [2006]
   Nyckelord :TEKNIKVETENSKAP; TECHNOLOGY; affibody; protein structure; coupled folding; NMR spectroscopy; protein stability; protein-protein interactions; binding thermodynamics; isothermal titration calorimetry; protein engineering;

   Sammanfattning : The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA-1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. LÄS MER

7. 5. Protein complexes : assembly, structure and function

   Detta är en avhandling från Umeå : Umeå university

   Författare :Kristina Wilhelm; Umeå universitet.; [2009]
   Nyckelord :HAMLET; ELOA; lysozyme; amyloid; Medical Biochemistry; medicinsk biokemi;

   Sammanfattning :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. LÄS MER