Sökning: "Platelet derived growth factor B-chain"
Hittade 5 avhandlingar innehållade orden Platelet derived growth factor B-chain.
1. Studies of platelet-derived growth factor (PDGF) B-chain and PDGF ß-receptors in rheumatoid arthritis and wound healing : characterization of the PDGF B-chain and PDGF ß-receptor expression
Sammanfattning : .... LÄS MER
2. Platelet-derived growth factor-induced signal transduction
Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER
3. Actions and interactions of insulin-like growth factor-I and insulin in vascular smooth muscle
Sammanfattning : Insulin-like growth factor-I (IGF-I) is a polypeptide with structural and biological similarities with insulin, and the receptors for IGF-I and insulin are homologous. The present investigation was devoted to the actions and interactions of IGF-I and insulin in vascular smooth muscle. LÄS MER
4. The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma
Sammanfattning : Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal aberrations involving chromosomes 17 and 22. LÄS MER
5. Paracrine and autocrine functions of PDGF in malignant disease
Sammanfattning : Growth factors and their receptors are frequently activated by mutations in human cancer. Platelet-derived growth factor (PDGF)-B and its tyrosine kinase receptor, the PDGF β-receptor, have been implicated in autocrine transformation as well as paracrine stimulation of tumor growth. LÄS MER