Sökning: "Neuroblastoma tumour"
Visar resultat 1 - 5 av 34 avhandlingar innehållade orden Neuroblastoma tumour.
1. Microenvironmental Impact on Tumour Cell Phenotype and Genotype in Adult and Paediatric Tumours
Sammanfattning : This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. LÄS MER
2. Gene therapy of neuroblastoma
Sammanfattning : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. LÄS MER
3. Genomic instability and genetic heterogeneity in neuroblastoma tumours
Sammanfattning : Neuroblastoma (NB), a tumour of the sympathetic nervous system and the most common malignant disease of early childhood, is responsible for 9% of paediatric cancer related deaths. Aggressive NB still constitutes a major clinical problem with survival rates of about 35%. LÄS MER
4. Polyamine analogues inhibit neuroblastoma cell growth
Sammanfattning : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. LÄS MER
5. Exploring novel therapeutic strategies in neuroblastoma
Sammanfattning : Neuroblastoma (NB) is the most frequently diagnosed extracranial tumour in children, which arises from transient embryonal tissue of the neural crest that fails to complete terminal differentiation into neurons. Even after completion of successful therapy, high risk neuroblastoma patients typically suffer from post-treatment induced toxicity which impacts on their ability to lead a normal life. LÄS MER