Sökning: "survivin"

Visar resultat 1 - 5 av 25 avhandlingar innehållade ordet survivin.

  1. 1. Structural and Interaction Studies of the Human Protein Survivin

    Författare :Maria-Jose Garcia-Bonete; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; apoptosis; protein interactions; X-ray crystallography; Bayesian inference;

    Sammanfattning : Cell division and cell death (apoptosis) are two essential processes to maintain the specific number of cells in all multicellular organisms. In humans, the misregulation of these processes leads to severe diseases, such as cancer, and neurological, inflammatory or autoimmune diseases. LÄS MER

  3. 2. The MEN 1 Pancreas : Tumor Development and Haploinsufficiency

    Författare :Margareta Halin Lejonklou; Britt Skogseid; Peter Stålberg; Andreea Barbu; Gerard Doherty; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN 1; PNET; tumor development; haploinsufficiency; survivin; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Sammanfattning : Multiple Endocrine Neoplasia Type I Syndrome (MEN 1) is a monogenic autosomal dominantly inherited cancer syndrome caused by a heterozygous loss of the MEN1 gene, predisposing for endocrine cell proliferation and tumor formation. MEN 1 carriers classically develop tumors in endocrine organs; the parathyroids, the endocrine pancreas, and the pituitary. LÄS MER

  4. 3. Prognostic and Predictive Factors in Bladder Cancer

    Författare :Tammer Hemdan; Per-Uno Malmström; Ulrika Segersten; Peter Boström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bladder cancer; BCG; cisplatin; STMN1; emmprin; survivin; CCTα; biomarker; immunohistochemistry; IHC; tissue microarray; TMA;

    Sammanfattning : Bladder cancer is a potentially curable malignancy; however in regards to the state of current therapy regimens, a plateau has been reached in both the non-muscle and muscle invasive types. To obtain effective treatment, and consequently a decreased mortality, it has become imperative to test and understand aspects affecting therapy response. LÄS MER

  5. 4. Polyamine analogues inhibit neuroblastoma cell growth

    Författare :Erika Söderstjerna; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; polyamine analogue; polyamines; apoptosis; neuroblastoma; MYCN;

    Sammanfattning : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. LÄS MER

  7. 5. The impact of Survivin, WRAP53β, and Hypoxia on treatment response in Head and Neck Cancer

    Författare :Katharina Tiefenböck-Hansson; Karin Roberg; Lovisa Farnebo; Stina Garvin; Eva Brun; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Squamous cell carcinoma (SCC) is the most common histological type of cancer in the head and neck region and arises in the epithelial mucosa of the upper aerodigestive tract. Approximately one and a half million people are living with the diagnosis. LÄS MER