Sökning: "Jorge Ruas"

Hittade 2 avhandlingar innehållade orden Jorge Ruas.

1. 1. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

   Författare :Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

   Sammanfattning : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. LÄS MER

3. 2. Molecular mechanisms mediating development of pulmonary cachexia in COPD

   Författare :Vladimir Basic; Jorge Ruas; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; COPD; cachexia; atrophy; cigarette smoke; myogenesis; angiogenesis; Biomedicin; Biomedicine; Biokemi; Biochemistry;

   Sammanfattning : Cigarette smoking (CS) represents the main causative agent underlying development and progress of COPD. Recently, involvement of CS in the pathogenesis of COPDassociated muscle abnormalities is becoming increasingly evident. Nevertheless, involved triggers and underlying mechanisms remain largely unknown. LÄS MER