Sökning: "Jordi Llop Roig"

Hittade 1 avhandling innehållade orden Jordi Llop Roig.

1. 1. One-click away from higher contrast : Improvements to peripheral clearance for same-day immunoPET in Alzheimer’s disease

   Författare :Eva Schlein; Dag Sehlin; Jordi Llop Roig; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease AD ; bispecific antibody; Amyloid-β Aβ ; Receptor mediated transcytosis RMT ; Neonatal Fc receptor FcRn ; Blood-brain barrier BBB ; Inverse electron demand Diels−Alder reaction IEDDA; pre-targeting; tetrazine; bio-orthogonal; Fluorine-18; clearing agent;

   Sammanfattning : The brain is a challenging target for antibody-based positron emission tomography (immunoPET) to image amyloid-beta (Aβ). Antibodies detect pathology with high sensitivity, but due to their size and biological half-life, they cause a high background radiation, if radiolabelled. LÄS MER