Sökning: "Gene expression analyses"

Visar resultat 1 - 5 av 411 avhandlingar innehållade orden Gene expression analyses.

1. 1. Gene Expression Studies of Hematologic Malignacies

   Författare :Anna Andersson; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

   Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER

3. 2. Network and gene expression analyses for understanding protein function

   Författare :Oliver Frings; Erik Sonnhammer; Rune Linding; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biological networks; network inference; network analysis; clustering; network module; network crosstalk; expression analysis; gene signature; biomarker; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Biological function is the result of a complex network of functional associations between genes or their products. Modeling the dynamics underlying biological networks is one of the big challenges in bioinformatics. LÄS MER

4. 3. Avian Genome Evolution - Gene Expression, Gene Divergence and Sexual Dimorphism

   Författare :Sara Naurin; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sex chromosome; avian genome evolution; gene expression; sexual dimorphism; Z chromosome;

   Sammanfattning : This study has focused on: (i) differences in how males and females use the genes in the genome, (ii) how sex chromosomes evolve and (iii) how the evolutionary rate of genes are affected by the chromosome on which they are located on and the gene expression level they experience. A large-scale microarray was developed for the zebra finch, Taeniopygia guttata and techniques were developed so that this microarray could also be used for wild passerine birds. LÄS MER

5. 4. Gene expression in carcinogenesis

   Författare :Heléne Fischer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : It is important to understand the processes of carcinogenesis and to find out which genes are involved . One way to study the process on a molecular basis is to identify differences in gene expression. LÄS MER

7. 5. Analyses of genomic and gene expression signatures

   Författare :Rickard Sandberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Microarray; comparative genomics; differential gene expression; cell lines; computational biology;

   Sammanfattning : Biology has entered a challenging, information-intense period where computational experiments are complementing traditional experiments. A plethora of new techniques have allowed biological processes to be investigated on a global scale. LÄS MER